Daily Sports Picks — Tuesday, September 22, 2026
NFL is dark. College waits until Friday. Doubleheader in the Bronx, Yamamoto under the lights, Wheeler at home. Five plays.
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1. Rays ML at Yankees (Game 1)
1:05 PM ET · Yankee Stadium
Nick Martinez (15–4, 2.94 ERA) against Carlos Rodón (6–3, 2.95 ERA). Tampa Bay is 22–7 when Martinez starts. The Rays sit 95–60 and lead the East by six. New York needs a sweep to stay in the division race. Two similar ERAs, plus-money on the better club. Playable to even money.
Confidence: Medium-High
2. Phillies −1.5 vs Brewers
6:40 PM ET · Citizens Bank Park
Zack Wheeler (13–5, 2.99 ERA) against Dustin May (7–9, 4.61 ERA). Milwaukee is 98–58, best record in baseball. That is priced into the moneyline. Wheeler at home against a 4.61 ERA is the mismatch. A run and a half at plus money is the number. Playable to −1.5 (+145).
Confidence: Medium-High
3. Tigers −1.5 vs Nationals
6:40 PM ET · Comerica Park
Drew Anderson (5–6, 3.62 ERA) against Jackson Kent (1–4, 6.40 ERA). Detroit just handled this club 9–2. Washington is 73–84. Home favorite, bad opponent, bad starter. Playable to −1.5 (+130).
Confidence: Medium-High
4. Red Sox / Guardians Under 6.5
6:45 PM ET · Fenway Park
Payton Tolle (9–6, 3.02 ERA) against Parker Messick (12–9, 2.57 ERA). Two arms who miss contact, a total sitting on 6.5, under at plus money. Fenway can play small in September. Lean the total. Playable to 6.5.
Confidence: Medium
5. Dodgers ML vs Padres
10:10 PM ET · Dodger Stadium
Yoshinobu Yamamoto (14–8, 2.51 ERA, 0.87 WHIP) against Michael King (12–9, 3.03 ERA). Los Angeles is 96–60 and 50–28 at home. Yamamoto has allowed one earned or fewer in three of his last four. San Diego is on a five-game heater and scored 40 in that stretch. Credit the streak. Still taking the best WHIP in the league at home around −121. Playable to −135.
Confidence: Medium-High
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Card recap
Rays ML · Phillies −1.5 · Tigers −1.5 · Red Sox/Guardians Under 6.5 · Dodgers ML
Vote the play you like most. Drop your card in the comments.
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21+ only. Gambling problem? Call 1-800-GAMBLER. This is opinion, not a guarantee. Bet what you can afford to lose. Lines move. Confirm before you fire.
